RNA REGULATION IN HEALTH AND DISEASE

We study Myotonic Dystrophy (DM), the most common form of muscular dystrophy in adults. DM affects almost all tissues of the body and has become a paradigm for diseases of RNA toxicity. It is a member of the microsatellite repeat diseases, which includes Huntington's disease, spinocerebellar ataxias, and potentially ALS. As a result of the expanded repeat that is transcribed in DM cells, multiple steps of gene expression are perturbed, including pre-mRNA splicing and RNA localization. We seek to combine high-throughput, global approaches with high-resolution, single-molecule approaches in order to study regulation of these processes, and relate them to symptoms experienced by individuals who suffer from DM and other neuromuscular diseases.

News

  • May 6, 2014

    Lab member Ona McConnell is featured in Ivy League Athletes, a book about "nine student-athletes from seven Ivy League campuses through the 2011–2012 season", and the "qualities of heart, mind, and body that got them there and allow them to prosper on the field and in the classroom.

  • May 9, 2014

    Our video was selected as a winner in the NIH Common Fund Video Contest! It will featured at the NIH Common Fund 10 Year Commemoration Symposium in June.

  • March 1, 2014

    Eric is guest speaker at the Promise To Kate gala dinner event in Jacksonville, Florida. Promise To Kate was founded to "honor Kate Conte and help fund research for myotonic dystrophy".

  • October 16, 2013

    Eric co-chairs the keynote session at the 9th International Myotonic Dystrophy Consortium Meeting.

  • September 30, 2013

    Eric receives the NIH Early Independence Award. Given through the NIH Common Fund as part of its "High-Risk, High-Reward Program", this award provides a mechanism for exceptional early career scientists to move rapidly into independent research positions by essentially omitting the traditional post-doctoral training period.

  • September 16, 2013

    Eric co-hosts Strength, Science & Stories of Inspiration, a benefit event in Boston aimed at bringing together all stakeholders for muscle diseases. Click here to see the Facebook page for this annual event.

Contact

  • Fedex Packages/Lab:

    Eric Wang Lab
    Koch Institute at MIT
    Building 76 Rm 311
    77 Massachusetts Ave
    Cambridge, MA 02139

  • USPS Mail/Office:

    Eric Wang
    Koch Institute at MIT
    Building 76 Rm 361F
    77 Massachusetts Ave
    Cambridge, MA 02139
    (617) 324-4404